Finding a Clinical Trial

In addition to the many approved treatment options available for individuals with bladder and bowel control problems, there is exciting research underway. On this page of the NAFC site, you can read about organizations and companies conducting clinical trials in an effort to find more or better treatment options for patients like you.

Please take a moment to read some important information about participating in a clinical trial.

Research and Clinical Trials

Novasys Medical's Study on Renessa® for Female Stress Urinary Incontinence
For many patients, surgery may be the best option for a cure from female stress urinary incontinence (SUI).  However, some women have experienced less than optimal surgical outcomes leaving them with ongoing urine leakage. Novasys Medical is now evaluating a non-surgical treatment called Renessa® for women in the U.S. who continue to experience incontinence symptoms after surgery for SUI.  For more information on this study, or to see if you may be eligible to participate, please call 1-866-633-9454, or visit http://renessaresearch.com/.

BRIDGES Study for Overactive Bladder
The BRIDGES Study is a multi-center research study comparing fesoterodine (Toviaz), an FDA approved medication, to placebo in women diagnosed with urgency urinary incontinence and overactive bladder by the 3 Incontinence Questions (3IQ). Approximately 636 women, at 13 clinical sites across the United States, will receive 12 weeks of fesoterodine or matching placebo. Women who complete the 12-week study will be offered open-label fesoterodine (Toviaz) for an additional 9 months. For more information, please click here.

Beaumont Hospital's Study on Stem Cells for Female Stress Urinary Incontinence
Urologists at Beaumont Hospital in Royal Oaks, Michigan are the first in the United States to research the use of autologous stem cells for female stress urinary incontinence. Urologists plan to use stem cells harvested from 48 female participants' thigh muscle to conduct this research. The stem cells will then be duplicated and injected into the participants' muscles that control urination. Participation will last 12-14 months. There is no charge for study-related tests and procedures. To learn more, call nurse Debbie Hasenau at 1-248-551-3355.

Biosante Pharmaceuticals' Bloom Study
Biosante Pharmaceuticals is currently recruiting women to take part in a study of Hypoactive Sexual Desire Disorder (HSDD). The purpose of the study is to determine the safety and effectiveness of LibiGel®, an investigational medication for HSDD. If you’re a woman at least 30 years of age experiencing a decrease in sexual desire, you are invited to see if you may qualify for the Bloom Study. To qualify, you must have gone through menopause or had your ovaries removed. Please click on the following link Bloom Study to learn more.

Bladder Pain Study
A new clinical trial is now enrolling patients with IC/PBS pain. This clinical trial is designed to see how well a study medicine for pain works at reducing moderate to severe IC/PBS pain. It will also explore the affect of the medicine on urination frequency and urgency. If you qualify for the study, you will receive 2 injections of the study medicine (Tanezumab) at the clinic, 8 weeks apart. Over the 24-week study period, after the screening process, you will need to visit the study center 7 times, with at least 3 telephone contacts by the research site (For some patients the study might be a total of 32 weeks). You will carefully monitor your pain symptoms using an electronic diary over the course of the study.

For more information on this study, visit the clinical trial web site here.

Forest Research Institute's Study on Irritable Bowel Syndrome with Constipation
A phase 3, randomized, double-blind, placebo-controlled, parallel-group trial of linaclotide administered orally for 12 weeks followed by a 4-week randomized withdrawal period in patients with Irritable Bowel Syndrome with constipation. The purpose of the study is to determine the efficacy and safety of linaclotide administered to patients with irritable bowel syndrome with constipation (IBS-C). This study is sponsored by Forest Research Institute. To learn more, please click here.

The American Urological Association (AUA)
Founded in 1902, the AUA is the premier professional association for the advancement of urologic patient care, and works to ensure that its members are current on the latest research and practices in urology.

The AUA’s Office of Research was founded in June 2001 with the mission of improving the care and treatment of patients with urologic diseases by advancing urological research through expanded funding, increased participation, improved communication, and increased recognition and influence.

To search AUA's comprehensive list of industry-sponsored, government funded, and privately supported clinical trials please click on the following link: Clinical Trials Resource Center

The link above also provides clinical trial results and a listing of drugs that have recently been approved by the Food and Drug Administration (FDA).

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

The National Institute of Diabetes and Digestive and Kidney Diseases conducts and supports research on many of the most serious diseases affecting public health. The Institute supports much of the clinical research on the diseases of internal medicine and related sub-specialty fields as well as many basic science disciplines.

View a list of current urological studies.

National Institute of Health (NIH)
Founded in 1887, the National Institutes of Health is one of the world's foremost medical research centers, and the Federal focal point for medical research in the United States. The NIH, comprising 27 separate Institutes and Centers, is one of eight health agencies of the Public Health Service which, in turn, is part of the U.S. Department of Health and Human Services.

ClinicalResearch.NIH.gov provides regularly updated information about federally and privately supported clinical research in human volunteers. ClinicalResearch.NIH.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details.

Search current clinical trials.

The Urinary Incontinence Treatment Network (UITN)
The Urinary Incontinence Treatment Network (UITN) was established in July 2000 to study urinary incontinence in women. The UITN is supported by cooperative agreements from the National Institutes of Diabetes and Digestive Kidney Disease (NIDDK) in collaboration with the National Institute of Child Health and Human Development (NICDH), both branches of the National Institutes of Health (NIH). The network is comprised of a group of investigators from nine continence treatment centers and a biostatistical coordinating center.

Center for Information and Study on Clinical Research Participation
Created especially for patients, family members, healthcare professionals and members of the public, SearchClinicalTrials.org allows you to search multiple websites for clinical research in human volunteers, clinical study results, and medical news.

Review the "Research Participants Bill of Rights and Responsibilities for patient centered-clinical research to evaluate new therapies."